化合物SP-96 T41256
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Product IntroductionBioactivity英文名: SP-96描述: SP-96 是一种高效的特异性 Aurora B 抑制剂，IC50 为 0.316 nM。 SP-96 在 NCI60 筛选中显示特异性生长抑制，如 M
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Product Introduction
Bioactivity
英文名: SP-96
描述: SP-96 是一种高效的特异性 Aurora B 抑制剂，IC50 为 0.316 nM。 SP-96 在 NCI60 筛选中显示特异性生长抑制，如 MDA-MD-468 (GI50=107 nM)。 SP-96 可用于三阴性乳腺癌研究。
体外活性: SP-96 (63.2 nM) inhibits Aurora B activity in H460 cells by the characteristics of increased DNA content, and it increases cell volume with enormous nucleus. SP-96 shows >2000 fold selectivity against FLT3 (IC50=1475.6 nM) and KIT (IC50=1307.6 nM). SP-96 (0-2 µM) inhibits Aurora A with IC50 value of 18.975 nM. SP-96 (0-1 µM; 24 hours) is not promiscuous, rather selective for a few cell lines, it inhibits MDA-MB-468, CCRF-CEM, COLO 205 and A498 cell growth with GI50 values of 107 nM,47.4 nM, 50.3 nM and 53.2 nM, respectively[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 95 mg/mL (209.50 mM)
关键字: Breast Cancer | SP96 | hematopoiesis | Inhibitor | Aurora Kinase | SP 96 | Triple Negative | NCI60 | SP-96 | inhibit
相关产品: TAK-285 | MBM-17 | SNS-314 Mesylate | MBM-55 | AT9283 | CYC-116 | URMC-099 | Danusertib | XU1 | PF-03814735
相关库: Anti-Breast Cancer Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Epigenetics Compound Library | Anti-Cancer Active Compound Library | Covalent Inhibitor Library | Bioactive Compound Library
Bioactivity
英文名: SP-96
描述: SP-96 是一种高效的特异性 Aurora B 抑制剂，IC50 为 0.316 nM。 SP-96 在 NCI60 筛选中显示特异性生长抑制，如 MDA-MD-468 (GI50=107 nM)。 SP-96 可用于三阴性乳腺癌研究。
体外活性: SP-96 (63.2 nM) inhibits Aurora B activity in H460 cells by the characteristics of increased DNA content, and it increases cell volume with enormous nucleus. SP-96 shows >2000 fold selectivity against FLT3 (IC50=1475.6 nM) and KIT (IC50=1307.6 nM). SP-96 (0-2 µM) inhibits Aurora A with IC50 value of 18.975 nM. SP-96 (0-1 µM; 24 hours) is not promiscuous, rather selective for a few cell lines, it inhibits MDA-MB-468, CCRF-CEM, COLO 205 and A498 cell growth with GI50 values of 107 nM,47.4 nM, 50.3 nM and 53.2 nM, respectively[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 95 mg/mL (209.50 mM)
关键字: Breast Cancer | SP96 | hematopoiesis | Inhibitor | Aurora Kinase | SP 96 | Triple Negative | NCI60 | SP-96 | inhibit
相关产品: TAK-285 | MBM-17 | SNS-314 Mesylate | MBM-55 | AT9283 | CYC-116 | URMC-099 | Danusertib | XU1 | PF-03814735
相关库: Anti-Breast Cancer Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Epigenetics Compound Library | Anti-Cancer Active Compound Library | Covalent Inhibitor Library | Bioactive Compound Library
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