化合物SP-96 T41256

Product Introduction
Bioactivity


英文名: SP-96

描述: SP-96 是一种高效的特异性 Aurora B 抑制剂，IC50 为 0.316 nM。 SP-96 在 NCI60 筛选中显示特异性生长抑制，如 MDA-MD-468 (GI50=107 nM)。 SP-96 可用于三阴性乳腺癌研究。

体外活性: SP-96 (63.2 nM) inhibits Aurora B activity in H460 cells by the characteristics of increased DNA content, and it increases cell volume with enormous nucleus. SP-96 shows >2000 fold selectivity against FLT3 (IC50=1475.6 nM) and KIT (IC50=1307.6 nM). SP-96 (0-2 µM) inhibits Aurora A with IC50 value of 18.975 nM. SP-96 (0-1 µM; 24 hours) is not promiscuous, rather selective for a few cell lines, it inhibits MDA-MB-468, CCRF-CEM, COLO 205 and A498 cell growth with GI50 values of 107 nM,47.4 nM, 50.3 nM and 53.2 nM, respectively[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 95 mg/mL (209.50 mM)


关键字: Breast Cancer | SP96 | hematopoiesis | Inhibitor | Aurora Kinase | SP 96 | Triple Negative | NCI60 | SP-96 | inhibit

相关产品: TAK-285 | MBM-17 | SNS-314 Mesylate | MBM-55 | AT9283 | CYC-116 | URMC-099 | Danusertib | XU1 | PF-03814735

相关库: Anti-Breast Cancer Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Epigenetics Compound Library | Anti-Cancer Active Compound Library | Covalent Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途