戊二酸 T4794
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Product IntroductionBioactivity英文名: Glutaric acid描述: Glutaric acid 是一种 C5 二羧酸，是色氨酸和赖氨酸分解代谢途径中的中间体。Glutaric acid 影响周细胞的收缩性
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Product Introduction
Bioactivity
英文名: Glutaric acid
描述: Glutaric acid 是一种 C5 二羧酸，是色氨酸和赖氨酸分解代谢途径中的中间体。Glutaric acid 影响周细胞的收缩性和迁移。Glutaric acid 是 I 型戊二酸尿症的生物指标。
体外活性: Glutaric acid (1 and 2 mM) is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : Soluble
DMSO : 55 mg/mL (416.32 mM)
H2O : 5 mg/mL
关键字: Inhibitor | Glutaric acid | inhibit | Endogenous Metabolite
相关产品: Indole-3-acetamide | Urolithin B | Glucocerebrosidase | 2′-Deoxyadenosine 5′-monophosphate disodium | D-Ribose(mixture of isomers) | Ginsenoside Rh2 | Levomefolic Acid | 2'-Deoxyadenosine | 7α,25-Dihydroxycholesterol | L-Tryptophan
相关库: Human Endogenous Metabolite Library | Tobacco Monomer Library | Human Metabolite Library | Human Endogenous Metabolite Compound Library Plus | Natural Product Library for HTS | Microbial Natural Product Library | Gut Microbial Metabolite Library | NO PAINS Compound Library | Bioactive Compound Library | Natural Product Library
Bioactivity
英文名: Glutaric acid
描述: Glutaric acid 是一种 C5 二羧酸，是色氨酸和赖氨酸分解代谢途径中的中间体。Glutaric acid 影响周细胞的收缩性和迁移。Glutaric acid 是 I 型戊二酸尿症的生物指标。
体外活性: Glutaric acid (1 and 2 mM) is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : Soluble
DMSO : 55 mg/mL (416.32 mM)
H2O : 5 mg/mL
关键字: Inhibitor | Glutaric acid | inhibit | Endogenous Metabolite
相关产品: Indole-3-acetamide | Urolithin B | Glucocerebrosidase | 2′-Deoxyadenosine 5′-monophosphate disodium | D-Ribose(mixture of isomers) | Ginsenoside Rh2 | Levomefolic Acid | 2'-Deoxyadenosine | 7α,25-Dihydroxycholesterol | L-Tryptophan
相关库: Human Endogenous Metabolite Library | Tobacco Monomer Library | Human Metabolite Library | Human Endogenous Metabolite Compound Library Plus | Natural Product Library for HTS | Microbial Natural Product Library | Gut Microbial Metabolite Library | NO PAINS Compound Library | Bioactive Compound Library | Natural Product Library
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