戊二酸 T4794

Product Introduction
Bioactivity


英文名: Glutaric acid

描述: Glutaric acid 是一种 C5 二羧酸，是色氨酸和赖氨酸分解代谢途径中的中间体。Glutaric acid 影响周细胞的收缩性和迁移。Glutaric acid 是 I 型戊二酸尿症的生物指标。

体外活性: Glutaric acid (1 and 2 mM) is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : Soluble
DMSO : 55 mg/mL (416.32 mM)
H2O : 5 mg/mL


关键字: Inhibitor | Glutaric acid | inhibit | Endogenous Metabolite

相关产品: Indole-3-acetamide | Urolithin B | Glucocerebrosidase | 2′-Deoxyadenosine 5′-monophosphate disodium | D-Ribose(mixture of isomers) | Ginsenoside Rh2 | Levomefolic Acid | 2'-Deoxyadenosine | 7α,25-Dihydroxycholesterol | L-Tryptophan

相关库: Human Endogenous Metabolite Library | Tobacco Monomer Library | Human Metabolite Library | Human Endogenous Metabolite Compound Library Plus | Natural Product Library for HTS | Microbial Natural Product Library | Gut Microbial Metabolite Library | NO PAINS Compound Library | Bioactive Compound Library | Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途