槐黄烷酮 G T5S1000
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Product IntroductionBioactivity英文名: Sophoraflavanone G描述: Sophoraflavanone G (Kushenol F) 是从苦参中提取到的一种天然产物，通过抑制 MAPK 相关通路诱
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Product Introduction
Bioactivity
英文名: Sophoraflavanone G
描述: Sophoraflavanone G (Kushenol F) 是从苦参中提取到的一种天然产物，通过抑制 MAPK 相关通路诱导 MDA-MB-231 和 HL-60 细胞凋亡，具有抗肿瘤和抗炎特性。
体外活性: Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells in a dose-dependent manner, and induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated 'intrinsic' pathway [1]. Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner (IC50: 29.7 μM) [2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 25 mg/mL (58.89 mM)
关键字: Inhibitor | anti-infammatory | Sophoraflavanone G | HL60 | inhibit | Apoptosis
相关产品: Etalocib | PD168393 | Bilobalide | Ethyl pyruvate | Oncrasin-1 | α-Thujone | SGI-1776 | 10-Gingerol | Diphenyl disulfide | Xanthatin
相关库: Anti-Cancer Compound Library | Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Natural Product Library for HTS | Apoptosis Compound Library | Tibetan medicine Compound Library | NO PAINS Compound Library | Bioactive Compound Library
Bioactivity
英文名: Sophoraflavanone G
描述: Sophoraflavanone G (Kushenol F) 是从苦参中提取到的一种天然产物，通过抑制 MAPK 相关通路诱导 MDA-MB-231 和 HL-60 细胞凋亡，具有抗肿瘤和抗炎特性。
体外活性: Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells in a dose-dependent manner, and induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated 'intrinsic' pathway [1]. Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner (IC50: 29.7 μM) [2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 25 mg/mL (58.89 mM)
关键字: Inhibitor | anti-infammatory | Sophoraflavanone G | HL60 | inhibit | Apoptosis
相关产品: Etalocib | PD168393 | Bilobalide | Ethyl pyruvate | Oncrasin-1 | α-Thujone | SGI-1776 | 10-Gingerol | Diphenyl disulfide | Xanthatin
相关库: Anti-Cancer Compound Library | Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Natural Product Library for HTS | Apoptosis Compound Library | Tibetan medicine Compound Library | NO PAINS Compound Library | Bioactive Compound Library
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