Product IntroductionBioactivity英文名:
NLRP3/AIM2-IN-3描述: NLRP3/AIM2-IN-3 是一种独特的分子,能以物种特异性的方式抑制 NLRP3 和 AIM2 炎性体的激活。它对细胞裂解的 IC50 值为 0.077 ± 0.008 μ M。NLRP3/AIM2-IN-3是一种 NLRP3 和 AIM2 炎症体依赖性细胞裂解的强效抑制剂,对细胞裂解的 IC50 值为 0.077 ± 0.008 μ M。NLRP3/AIM2-IN-3 可抑制 LPS/nigericin 刺激的 THP-1 巨噬细胞的细胞裂解,其 IC50 值为 0.077 ± 0.008 μM。NLRP3/AIM2-IN-3 干扰了 NLRP3 或 AIM2 与桥接蛋白 ASC 的相互作用,抑制了 ASC 的寡聚。
体外活性: NLRP3/AIM2-IN-3 (0-100 μM) exhibits significant inhibitory activity against NLRP3 and AIM2, but not NLRC4-dependent activation of caspase-1 and release of IL-1b in human THP-1 macrophages Significant inhibitory effect.[1] NLRP3/AIM2-IN-3 inhibits IL-1b secretion from human THP-1 macrophages with IC50 of 0.098 μM, nearly 150-fold and 500-fold more potent than NLRP3/AIM2-IN-3 for J774A.1 (14.62 μM) and Bone marrow-derived macrophages (BMDM) (48.98 μM).[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 225.0 mg/mL (844.9 mM)
Methanol : 45.0 mg/mL (169.0 mM)
相关产品:
NLRP3/AIM2-IN-2 |
JC2-11相关库:
Anti-Cancer Compound Library |
Bioactive Compounds Library Max |
Inhibitor Library |
Bioactive Compound Library