Product Introduction
Bioactivity


英文名: BDA-366

描述: BDA-366 是一种有效的 Bcl2 拮抗剂，以高亲和力和选择性 (Ki = 3.3 nM) 结合 Bcl2-BH4 结构域。 BDA-366 诱导 Bcl2 的构象变化，从而消除其抗凋亡功能，将其从存活分子转变为细胞死亡诱导剂。 BDA-366 抑制肺癌细胞的生长。

体外活性: NSC 228155 promotes transactivation of several RTKs, including ErbB2 and ErbB3, Insulin R and IGF-1 R receptors in the cells. It stimulates dimerization of sEGFR domain II[1]. NSC 228155 can rapidly move across cell membranes and disperse within both cytoplasmic and nuclear compartments. It rapidly generates hydrogen peroxide within cells[2]. NSC 228155 is also a potent inhibitor of KIX-KID interaction(IC50 = 0.36 μM), but it is not particularly selective against CREB-mediated gene transcription in HEK 293T cells[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 5 mg/mL (11.8 mM)
DMSO : 78 mg/mL (184.2 mM)


关键字: Inhibitor | Antitumor | Bcl-2 Family | inhibit | Bcl2-BH4 domain | Anticancer | BDA 366 | Antiapoptotic function | BDA-366 | BDA366 | Lung cancer

相关产品: WEHI-539 hydrochloride | Dehydrocorydaline | BI-3812 | Sabutoclax | (E/Z)-TG003 | Bax activator-1 | Metaproterenol | Docetaxel trihydrate | Sappanchalcone | ABT-737

相关库: Anti-Cancer Compound Library | Mitochondria-Targeted Compound Library | Anti-Lung Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Highly Selective Inhibitor Library | Anti-Cancer Active Compound Library | PPI Inhibitor Library | Cuproptosis Compound Library | Bioactive Compound Library