化合物BDA-366 T6778

Product Introduction
Bioactivity


英文名: BDA-366

描述: BDA-366 是一种有效的 Bcl2 拮抗剂，以高亲和力和选择性 (Ki = 3.3 nM) 结合 Bcl2-BH4 结构域。 BDA-366 诱导 Bcl2 的构象变化，从而消除其抗凋亡功能，将其从存活分子转变为细胞死亡诱导剂。 BDA-366 抑制肺癌细胞的生长。

体外活性: NSC 228155 promotes transactivation of several RTKs, including ErbB2 and ErbB3, Insulin R and IGF-1 R receptors in the cells. It stimulates dimerization of sEGFR domain II[1]. NSC 228155 can rapidly move across cell membranes and disperse within both cytoplasmic and nuclear compartments. It rapidly generates hydrogen peroxide within cells[2]. NSC 228155 is also a potent inhibitor of KIX-KID interaction(IC50 = 0.36 μM), but it is not particularly selective against CREB-mediated gene transcription in HEK 293T cells[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 5 mg/mL (11.8 mM)
DMSO : 78 mg/mL (184.2 mM)


关键字: Inhibitor | Antitumor | Bcl-2 Family | inhibit | Bcl2-BH4 domain | Anticancer | BDA 366 | Antiapoptotic function | BDA-366 | BDA366 | Lung cancer

相关产品: WEHI-539 hydrochloride | Dehydrocorydaline | BI-3812 | Sabutoclax | (E/Z)-TG003 | Bax activator-1 | Metaproterenol | Docetaxel trihydrate | Sappanchalcone | ABT-737

相关库: Anti-Cancer Compound Library | Mitochondria-Targeted Compound Library | Anti-Lung Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Highly Selective Inhibitor Library | Anti-Cancer Active Compound Library | PPI Inhibitor Library | Cuproptosis Compound Library | Bioactive Compound Library

化合物BDA-366 T6778信息由TargetMol中国为您提供，如您想了解更多关于化合物BDA-366 T6778报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途