化合物RHPS4 T6967
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Product IntroductionBioactivity英文名: RHPS4描述: RHPS4 (RHPS 4 methosulfate) 是 DNA 损伤诱导剂，是一种有效的亚微摩尔端粒酶抑制剂，IC50为0.33 μM。体外活性:
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Product Introduction
Bioactivity
英文名: RHPS4
描述: RHPS4 (RHPS 4 methosulfate) 是 DNA 损伤诱导剂，是一种有效的亚微摩尔端粒酶抑制剂，IC50为0.33 μM。
体外活性: CP 673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM, exhibits >450-fold selectivity over other angiogenic receptors. In glioblastoma tumors, CP-673451 (33 mg/kg) provides >50% inhibition of PDGFR-β receptor for 4 hours corresponding to an EC50 of 120 ng/mL in plasma at Cmax. In a sponge angiogenesis model, CP-673451 inhibits 70% of PDGF-BB-stimulated angiogenesis at a dose of 3 mg/kg (q.d. ×5, p.o., corresponding to 5.5 ng/mL at Cmax).[1] CP-673451 decreases cell proliferation rate through mechanisms involving reduced phosphorylation of GSK-3α and GSK-3β. In both RD and RUCH2 cultures, CP-673451 impairs rhabdosphere-forming capacity and cell differentiation, causes increased senescence. [2]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 91 mg/mL (198.48 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
关键字: HT29 | Telomerase | RHPS-4 | NSC 714187 | RHPS4 | breast | Apoptosis | cancer | Inhibitor | inhibit | NSC-714187 | M14 | PC3 | H460 | RHPS 4 | H2AX | CG5
相关产品: Ionomycin calcium | Zoledronic acid monohydrate | Capsaicin | Clofarabine | Ganoderic acid D | Mocetinostat | Geranylgeraniol | Linalool | PRMT6-IN-3 | SP2509
相关库: Anti-Aging Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | DNA Damage & Repair Compound Library | Target-Focused Phenotypic Screening Library | Preclinical Compound Library | Bioactive Compound Library
Bioactivity
英文名: RHPS4
描述: RHPS4 (RHPS 4 methosulfate) 是 DNA 损伤诱导剂，是一种有效的亚微摩尔端粒酶抑制剂，IC50为0.33 μM。
体外活性: CP 673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM, exhibits >450-fold selectivity over other angiogenic receptors. In glioblastoma tumors, CP-673451 (33 mg/kg) provides >50% inhibition of PDGFR-β receptor for 4 hours corresponding to an EC50 of 120 ng/mL in plasma at Cmax. In a sponge angiogenesis model, CP-673451 inhibits 70% of PDGF-BB-stimulated angiogenesis at a dose of 3 mg/kg (q.d. ×5, p.o., corresponding to 5.5 ng/mL at Cmax).[1] CP-673451 decreases cell proliferation rate through mechanisms involving reduced phosphorylation of GSK-3α and GSK-3β. In both RD and RUCH2 cultures, CP-673451 impairs rhabdosphere-forming capacity and cell differentiation, causes increased senescence. [2]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 91 mg/mL (198.48 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
关键字: HT29 | Telomerase | RHPS-4 | NSC 714187 | RHPS4 | breast | Apoptosis | cancer | Inhibitor | inhibit | NSC-714187 | M14 | PC3 | H460 | RHPS 4 | H2AX | CG5
相关产品: Ionomycin calcium | Zoledronic acid monohydrate | Capsaicin | Clofarabine | Ganoderic acid D | Mocetinostat | Geranylgeraniol | Linalool | PRMT6-IN-3 | SP2509
相关库: Anti-Aging Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | DNA Damage & Repair Compound Library | Target-Focused Phenotypic Screening Library | Preclinical Compound Library | Bioactive Compound Library
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