化合物RHPS4 T6967

Product Introduction
Bioactivity


英文名: RHPS4

描述: RHPS4 (RHPS 4 methosulfate) 是 DNA 损伤诱导剂，是一种有效的亚微摩尔端粒酶抑制剂，IC50为0.33 μM。

体外活性: CP 673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM, exhibits >450-fold selectivity over other angiogenic receptors. In glioblastoma tumors, CP-673451 (33 mg/kg) provides >50% inhibition of PDGFR-β receptor for 4 hours corresponding to an EC50 of 120 ng/mL in plasma at Cmax. In a sponge angiogenesis model, CP-673451 inhibits 70% of PDGF-BB-stimulated angiogenesis at a dose of 3 mg/kg (q.d. ×5, p.o., corresponding to 5.5 ng/mL at Cmax).[1] CP-673451 decreases cell proliferation rate through mechanisms involving reduced phosphorylation of GSK-3α and GSK-3β. In both RD and RUCH2 cultures, CP-673451 impairs rhabdosphere-forming capacity and cell differentiation, causes increased senescence. [2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 91 mg/mL (198.48 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)


关键字: HT29 | Telomerase | RHPS-4 | NSC 714187 | RHPS4 | breast | Apoptosis | cancer | Inhibitor | inhibit | NSC-714187 | M14 | PC3 | H460 | RHPS 4 | H2AX | CG5

相关产品: Ionomycin calcium | Zoledronic acid monohydrate | Capsaicin | Clofarabine | Ganoderic acid D | Mocetinostat | Geranylgeraniol | Linalool | PRMT6-IN-3 | SP2509

相关库: Anti-Aging Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | DNA Damage & Repair Compound Library | Target-Focused Phenotypic Screening Library | Preclinical Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途