化合物PLX-5622 T7100
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Product IntroductionBioactivity英文名: PLX5622描述: PLX5622 是一种选择性的、高效的、能透过血脑屏障的、口服具有活性的 CSF1R 抑制剂 (IC50= 0.016 µM;Ki= 5.9 nM)
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Product Introduction
Bioactivity
英文名: PLX5622
描述: PLX5622 是一种选择性的、高效的、能透过血脑屏障的、口服具有活性的 CSF1R 抑制剂 (IC50= 0.016 µM;Ki= 5.9 nM)，具有较好的药理学特性，可用于病程发展前和过程中，扩大的和特异性的小胶质细胞的消除。
体内活性: Treated pregnant dams with the CSF1R inhibitor PLX-5622. Approximately 99% of microglia were eliminated by embryonic day 15.5 (E15.5) after pregnant dams were placed on a PLX-5622 diet starting at E3.5. Following microglia depletion, Elevated numbers of apoptotic cells accumulating throughout the developing hypothalamus. Once the PLX-5622 diet was removed, microglia repopulated the postnatal brain within 7?days and did not appear to repopulate from Nestin+?precursors[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 16.67 mg/mL (42.15 mM)
关键字: Inhibitor | CSF-1 receptor | microglial | PLX 5622 | CSF1R | orally | pathology | inhibit | c-Fms | penetrant | preceding | brain | colony stimulating factor 1 receptor | CSF-1R | elimination | PLX5622
相关产品: cFMS Receptor Inhibitor II | IACS-9439 | Edicotinib | PLX5622 hemifumarate | Nampt-IN-1 | cFMS Receptor Inhibitor IV | c-Fms-IN-14 | AEE788 | OSI-930 | Anti-Mouse GM-CSF Antibody (MP1-22E9)
相关库: Drug Repurposing Compound Library | Cytokine Inhibitor Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Highly Selective Inhibitor Library | Tyrosine Kinase Inhibitor Library | Orally Active Compound Library
Bioactivity
英文名: PLX5622
描述: PLX5622 是一种选择性的、高效的、能透过血脑屏障的、口服具有活性的 CSF1R 抑制剂 (IC50= 0.016 µM;Ki= 5.9 nM)，具有较好的药理学特性，可用于病程发展前和过程中，扩大的和特异性的小胶质细胞的消除。
体内活性: Treated pregnant dams with the CSF1R inhibitor PLX-5622. Approximately 99% of microglia were eliminated by embryonic day 15.5 (E15.5) after pregnant dams were placed on a PLX-5622 diet starting at E3.5. Following microglia depletion, Elevated numbers of apoptotic cells accumulating throughout the developing hypothalamus. Once the PLX-5622 diet was removed, microglia repopulated the postnatal brain within 7?days and did not appear to repopulate from Nestin+?precursors[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 16.67 mg/mL (42.15 mM)
关键字: Inhibitor | CSF-1 receptor | microglial | PLX 5622 | CSF1R | orally | pathology | inhibit | c-Fms | penetrant | preceding | brain | colony stimulating factor 1 receptor | CSF-1R | elimination | PLX5622
相关产品: cFMS Receptor Inhibitor II | IACS-9439 | Edicotinib | PLX5622 hemifumarate | Nampt-IN-1 | cFMS Receptor Inhibitor IV | c-Fms-IN-14 | AEE788 | OSI-930 | Anti-Mouse GM-CSF Antibody (MP1-22E9)
相关库: Drug Repurposing Compound Library | Cytokine Inhibitor Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Highly Selective Inhibitor Library | Tyrosine Kinase Inhibitor Library | Orally Active Compound Library
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