化合物PLX-5622 T7100

Product Introduction
Bioactivity


英文名: PLX5622

描述: PLX5622 是一种选择性的、高效的、能透过血脑屏障的、口服具有活性的 CSF1R 抑制剂 (IC50= 0.016 µM;Ki= 5.9 nM)，具有较好的药理学特性，可用于病程发展前和过程中，扩大的和特异性的小胶质细胞的消除。

体内活性: Treated pregnant dams with the CSF1R inhibitor PLX-5622. Approximately 99% of microglia were eliminated by embryonic day 15.5 (E15.5) after pregnant dams were placed on a PLX-5622 diet starting at E3.5. Following microglia depletion, Elevated numbers of apoptotic cells accumulating throughout the developing hypothalamus. Once the PLX-5622 diet was removed, microglia repopulated the postnatal brain within 7?days and did not appear to repopulate from Nestin+?precursors[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 16.67 mg/mL (42.15 mM)


关键字: Inhibitor | CSF-1 receptor | microglial | PLX 5622 | CSF1R | orally | pathology | inhibit | c-Fms | penetrant | preceding | brain | colony stimulating factor 1 receptor | CSF-1R | elimination | PLX5622

相关产品: cFMS Receptor Inhibitor II | IACS-9439 | Edicotinib | PLX5622 hemifumarate | Nampt-IN-1 | cFMS Receptor Inhibitor IV | c-Fms-IN-14 | AEE788 | OSI-930 | Anti-Mouse GM-CSF Antibody (MP1-22E9)

相关库: Drug Repurposing Compound Library | Cytokine Inhibitor Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Highly Selective Inhibitor Library | Tyrosine Kinase Inhibitor Library | Orally Active Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途