Product Introduction
Bioactivity


英文名: BI-2865

描述: BI-2865 是一种非共价的泛-KRAS 抑制剂。BI-2865 可与 KRAS WT、G12C、G12D、G12V 和 G13D 突变体结合，KD 值 分别为 6.9、4.5、32、26、4.3 nM。BI-2865在对 表达 KRAS G12C、G12D 或 G12V 突变体的 BaF3 细胞实验的过程中显示出抗增殖活性 ，平均 IC50值大约为 140 nM。

体外活性: BI-2865 inhibits the proliferation of BaF3 cells expressing G12C, G12D or G12V mutant KRAS in the presence of IL-13 with a mean IC50 of approximately 140 nM.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 225.0 mg/mL (483.3 mM)


关键字: BI 2865 | BI-2865 | BI2865

相关产品: (S)-BAY-293 | MBQ-167 | 6H05 | Deltarasin | BQU57 | Rhosin hydrochloride | KRAS G12C inhibitor 15 | Atranorin | KRAS G12C inhibitor 16 | K-Ras G12C-IN-4

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Kinase Inhibitor Library | Inhibitor Library | Bioactive Compound Library