化合物BIX-01294 T7697
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Product IntroductionBioactivity英文名: BIX-01294描述: BIX-01294 是高度选择性的G9a 和GLP 组蛋白甲基转移酶可逆抑制剂。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/G
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Product Introduction
Bioactivity
英文名: BIX-01294
描述: BIX-01294 是高度选择性的G9a 和GLP 组蛋白甲基转移酶可逆抑制剂。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP，可诱导坏死性凋亡和自噬，具有抗肿瘤活性。
细胞实验: On the first day, cells were seeded in 96 well plates.?Twenty-four hours later, BIX-01294 was added at the indicated concentrations in each well.?After treatment by BIX-01294 for another 24 h, we used 10% TCA to immobilize the cells and then evaluated the living cell numbers using the sulforhodamine B assay as previously described[1]
体外活性: BIX-01294 induced caspase-dependent apoptosis in human bladder cancer cells.?BIX-01294 stimulates endoplasmic reticulum stress (ER stress) and up-regulated expression of PMAIP1 through DDIT3 up-regulation.?Furthermore, down-regulation of the deubiquitinase USP9X by BIX-01294 results in downstream reduction of MCL1 expression, leading to apoptosis eventually[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 98 mg/mL (163.33 mM)
关键字: PRMT1 | recurrent | Autophagy | H3K9me3 | Inhibitor | BIX-01294 | Cdkn1a | inhibit | p53 | Gadd45a | MLKL | BIX 01294 | Histone Methyltransferase | SUV39H1(H320R) | H3K9me2 | BIX01294 | p21
相关产品: HLCL-61 hydrochloride | Tazemetostat hydrobromide | EPZ011989 | 3-deazaneplanocin A HCl | Amodiaquine | MM-102 TFA | Antitumor agent-101 | EED226 | TP-064 | SGC2085 HCl
相关库: Anti-Aging Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Stem Cell Differentiation Compound Library | Reprogramming Compound Library | Methylation Compound Library | NO PAINS Compound Library | Chromatin Modification Compound Library
Bioactivity
英文名: BIX-01294
描述: BIX-01294 是高度选择性的G9a 和GLP 组蛋白甲基转移酶可逆抑制剂。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP，可诱导坏死性凋亡和自噬，具有抗肿瘤活性。
细胞实验: On the first day, cells were seeded in 96 well plates.?Twenty-four hours later, BIX-01294 was added at the indicated concentrations in each well.?After treatment by BIX-01294 for another 24 h, we used 10% TCA to immobilize the cells and then evaluated the living cell numbers using the sulforhodamine B assay as previously described[1]
体外活性: BIX-01294 induced caspase-dependent apoptosis in human bladder cancer cells.?BIX-01294 stimulates endoplasmic reticulum stress (ER stress) and up-regulated expression of PMAIP1 through DDIT3 up-regulation.?Furthermore, down-regulation of the deubiquitinase USP9X by BIX-01294 results in downstream reduction of MCL1 expression, leading to apoptosis eventually[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 98 mg/mL (163.33 mM)
关键字: PRMT1 | recurrent | Autophagy | H3K9me3 | Inhibitor | BIX-01294 | Cdkn1a | inhibit | p53 | Gadd45a | MLKL | BIX 01294 | Histone Methyltransferase | SUV39H1(H320R) | H3K9me2 | BIX01294 | p21
相关产品: HLCL-61 hydrochloride | Tazemetostat hydrobromide | EPZ011989 | 3-deazaneplanocin A HCl | Amodiaquine | MM-102 TFA | Antitumor agent-101 | EED226 | TP-064 | SGC2085 HCl
相关库: Anti-Aging Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Stem Cell Differentiation Compound Library | Reprogramming Compound Library | Methylation Compound Library | NO PAINS Compound Library | Chromatin Modification Compound Library
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