化合物BIX-01294 T7697

Product Introduction
Bioactivity


英文名: BIX-01294

描述: BIX-01294 是高度选择性的G9a 和GLP 组蛋白甲基转移酶可逆抑制剂。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP，可诱导坏死性凋亡和自噬，具有抗肿瘤活性。

细胞实验: On the first day, cells were seeded in 96 well plates.?Twenty-four hours later, BIX-01294 was added at the indicated concentrations in each well.?After treatment by BIX-01294 for another 24 h, we used 10% TCA to immobilize the cells and then evaluated the living cell numbers using the sulforhodamine B assay as previously described[1]

体外活性: BIX-01294 induced caspase-dependent apoptosis in human bladder cancer cells.?BIX-01294 stimulates endoplasmic reticulum stress (ER stress) and up-regulated expression of PMAIP1 through DDIT3 up-regulation.?Furthermore, down-regulation of the deubiquitinase USP9X by BIX-01294 results in downstream reduction of MCL1 expression, leading to apoptosis eventually[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 98 mg/mL (163.33 mM)


关键字: PRMT1 | recurrent | Autophagy | H3K9me3 | Inhibitor | BIX-01294 | Cdkn1a | inhibit | p53 | Gadd45a | MLKL | BIX 01294 | Histone Methyltransferase | SUV39H1(H320R) | H3K9me2 | BIX01294 | p21

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相关库: Anti-Aging Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Stem Cell Differentiation Compound Library | Reprogramming Compound Library | Methylation Compound Library | NO PAINS Compound Library | Chromatin Modification Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途