化合物AZD-7325 T7699
面议
- TargetMol
- 生产商
- 进口
- 美国
- 现货
- 全国
- 7
- 0
Product IntroductionBioactivity英文名: AZD7325描述: AZD7325 (AZD-7325) 是具有口服活性的α2和α3受体正向别构调节剂，Ki 分别是 0.3 和 1.3 nM。它是中等 CYP1A2和
AI问答
配套的仪器设备？
可以搭配的相关耗材试剂？
耗材描述
Product Introduction
Bioactivity
英文名: AZD7325
描述: AZD7325 (AZD-7325) 是具有口服活性的α2和α3受体正向别构调节剂，Ki 分别是 0.3 和 1.3 nM。它是中等 CYP1A2和强效 CYP3A4诱导剂，有用于焦虑和 dravet 综合征相关的研究潜力。
动物实验: Animal Model:Male and female P18 - P20 F1.Scn1a+/- mice. Dosage:10, 17.8 or 31.6 mg/kg. Administration:Oral administration[1]
体内活性: AZD7325 on synaptic responses was more prominent in mice on the 129S6/SvEvTac background strain that has been demonstrated to be seizure resistant in the model of Dravet syndrome (Scn1a+/?) and in which the α2 GABAA receptor subunits are higher relative to in the C57BL/6J strain.?Consistent with this, treatment of mice with AZD7325 is associated with a higher temperature threshold for hyperthermia-induced seizures in Scn1a+/? mice without apparent sedative effects.?Our results in a model system indicate that selective targeting α2 is a potential therapeutic option for Dravet syndrome[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 9 mg/mL (25.4 mM)
关键字: modulator | effect | inhibit | Cytochrome P450 | Dravet | syndrome | Inhibitor | γ-Aminobutyric acid Receptor | CYPs | sedative | AZD 7325 | PAM | CYP1A2 | AZD7325 | Gamma-aminobutyric acid Receptor | anxiety | GABA Receptor
相关产品: Phthalic acid mono-2-ethylhexyl ester | Ketoconazole | 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate | (±)-N-3-Benzylnirvanol | 2,3-dihydrothieno-Thiadiazole Carboxylate | Germacrone | Bergaptol | Miltirone | Cedrol | Seneciphylline
相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | ReFRAME Related Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | Anti-Cancer Clinical Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library
Bioactivity
英文名: AZD7325
描述: AZD7325 (AZD-7325) 是具有口服活性的α2和α3受体正向别构调节剂，Ki 分别是 0.3 和 1.3 nM。它是中等 CYP1A2和强效 CYP3A4诱导剂，有用于焦虑和 dravet 综合征相关的研究潜力。
动物实验: Animal Model:Male and female P18 - P20 F1.Scn1a+/- mice. Dosage:10, 17.8 or 31.6 mg/kg. Administration:Oral administration[1]
体内活性: AZD7325 on synaptic responses was more prominent in mice on the 129S6/SvEvTac background strain that has been demonstrated to be seizure resistant in the model of Dravet syndrome (Scn1a+/?) and in which the α2 GABAA receptor subunits are higher relative to in the C57BL/6J strain.?Consistent with this, treatment of mice with AZD7325 is associated with a higher temperature threshold for hyperthermia-induced seizures in Scn1a+/? mice without apparent sedative effects.?Our results in a model system indicate that selective targeting α2 is a potential therapeutic option for Dravet syndrome[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 9 mg/mL (25.4 mM)
关键字: modulator | effect | inhibit | Cytochrome P450 | Dravet | syndrome | Inhibitor | γ-Aminobutyric acid Receptor | CYPs | sedative | AZD 7325 | PAM | CYP1A2 | AZD7325 | Gamma-aminobutyric acid Receptor | anxiety | GABA Receptor
相关产品: Phthalic acid mono-2-ethylhexyl ester | Ketoconazole | 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate | (±)-N-3-Benzylnirvanol | 2,3-dihydrothieno-Thiadiazole Carboxylate | Germacrone | Bergaptol | Miltirone | Cedrol | Seneciphylline
相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | ReFRAME Related Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | Anti-Cancer Clinical Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library
猜你喜欢
感兴趣产品