化合物AZD-7325 T7699

Product Introduction
Bioactivity


英文名: AZD7325

描述: AZD7325 (AZD-7325) 是具有口服活性的α2和α3受体正向别构调节剂，Ki 分别是 0.3 和 1.3 nM。它是中等 CYP1A2和强效 CYP3A4诱导剂，有用于焦虑和 dravet 综合征相关的研究潜力。

动物实验: Animal Model:Male and female P18 - P20 F1.Scn1a+/- mice. Dosage:10, 17.8 or 31.6 mg/kg. Administration:Oral administration[1]

体内活性: AZD7325 on synaptic responses was more prominent in mice on the 129S6/SvEvTac background strain that has been demonstrated to be seizure resistant in the model of Dravet syndrome (Scn1a+/?) and in which the α2 GABAA receptor subunits are higher relative to in the C57BL/6J strain.?Consistent with this, treatment of mice with AZD7325 is associated with a higher temperature threshold for hyperthermia-induced seizures in Scn1a+/? mice without apparent sedative effects.?Our results in a model system indicate that selective targeting α2 is a potential therapeutic option for Dravet syndrome[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 9 mg/mL (25.4 mM)


关键字: modulator | effect | inhibit | Cytochrome P450 | Dravet | syndrome | Inhibitor | γ-Aminobutyric acid Receptor | CYPs | sedative | AZD 7325 | PAM | CYP1A2 | AZD7325 | Gamma-aminobutyric acid Receptor | anxiety | GABA Receptor

相关产品: Phthalic acid mono-2-ethylhexyl ester | Ketoconazole | 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate | (±)-N-3-Benzylnirvanol | 2,3-dihydrothieno-Thiadiazole Carboxylate | Germacrone | Bergaptol | Miltirone | Cedrol | Seneciphylline

相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | ReFRAME Related Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | Anti-Cancer Clinical Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library

化合物AZD-7325 T7699信息由TargetMol中国为您提供，如您想了解更多关于化合物AZD-7325 T7699报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途