Product Introduction
Bioactivity


英文名: Diclofensine hydrochloride

描述: Diclofensine hydrochloride (Ro 8-4650 hydrochloride) 是一种高效单胺再摄取抑制剂，在大鼠脑突触体中能够阻断多巴胺 (IC50=0.74 nM)、去甲肾上腺素 (IC50=2.3 nM) 和 5-羟色胺 (IC50=3.7 nM)。

体外活性: The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE).?The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake.?PE sensitivity was also enhanced by diclofensine as well as after a single dose of desmethylimipramine (DMI).?In contrast to the common opinion that PE does not interact with the neuronal uptake mechanism, the increase in PE-induced blood pressure response after diclofensine and DMI suggests that PE, a nonbiogenic amine, does indeed enter into the peripheral adrenergic neuron[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 52 mg/mL (144.97 mM)


关键字: Diclofensine hydrochloride | SLC6A3 | DAT | Inhibitor | Ro 8-4650 | inhibit | Diclofensine | Diclofensine Hydrochloride | Dopamine Transporter | Ro 8-4650 Hydrochloride

相关产品: Risperidone | ABT 724 trihydrochloride | Metoclopramide hydrochloride | Ordopidine | PD-168077 maleate | Fluoroclebopride | Remoxipride hydrochloride | Fluphenazine decanoate | Pericyazine | Methyldopa

相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Anti-Parkinson's Disease Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | GPCR Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library