化合物Diclofensine hydrochloride T7745
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 34041-84-4 | ¥4,350.00 | 询底价 |
25 mg | 34041-84-4 | ¥1,590.00 | 询底价 |
50 mg | 34041-84-4 | ¥2,930.00 | 询底价 |
10 mg | 34041-84-4 | ¥763.00 | 询底价 |
5 mg | 34041-84-4 | ¥455.00 | 询底价 |
200 mg | 34041-84-4 | ¥6,190.00 | 询底价 |
1 mg | 34041-84-4 | ¥196.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Diclofensine hydrochloride
描述: Diclofensine hydrochloride (Ro 8-4650 hydrochloride) 是一种高效单胺再摄取抑制剂,在大鼠脑突触体中能够阻断多巴胺 (IC50=0.74 nM)、去甲肾上腺素 (IC50=2.3 nM) 和 5-羟色胺 (IC50=3.7 nM)。
体外活性: The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE).?The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake.?PE sensitivity was also enhanced by diclofensine as well as after a single dose of desmethylimipramine (DMI).?In contrast to the common opinion that PE does not interact with the neuronal uptake mechanism, the increase in PE-induced blood pressure response after diclofensine and DMI suggests that PE, a nonbiogenic amine, does indeed enter into the peripheral adrenergic neuron[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : 52 mg/mL (144.97 mM)
关键字: Diclofensine hydrochloride | SLC6A3 | DAT | Inhibitor | Ro 8-4650 | inhibit | Diclofensine | Diclofensine Hydrochloride | Dopamine Transporter | Ro 8-4650 Hydrochloride
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途