化合物GSK5182 T8370
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Product IntroductionBioactivity英文名: GSK5182描述: GSK5182 是高效选择性，具有口服活性的 ERRγ反向激动剂，其 IC50=79 nM，且不与其他核受体相互作用，包括 ERRα 和 ERα。它
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Product Introduction
Bioactivity
英文名: GSK5182
描述: GSK5182 是高效选择性，具有口服活性的 ERRγ反向激动剂，其 IC50=79 nM，且不与其他核受体相互作用，包括 ERRα 和 ERα。它还能增加肝癌细胞中 reactive oxyen species (ROS)的产生。
细胞实验: Cell Line:The human hepatoma cell line PLC/PRF/5. Concentration:0 μM, 10 μM, 20 μM. Incubation Time:0 hour, 24 hours, 48 hours, 72 hours
体外活性: Small interfering RNA (siRNA)-mediated knockdown of ERRγ (siRNA-ERRγ) or an ERRγ inverse agonist, GSK5182, were also used to examine the effects of ERRγ inhibition on the proliferation and growth of a human hepatoma cell line, PLC/PRF/5[1].
体内活性: a hyperinsulinemic-euglycemic clamp study and long-term studies of the antidiabetic effects of GSK5182, the ERRγ-specific inverse agonist, in db/db and DIO mice demonstrated that GSK5182 normalizes hyperglycemia mainly through inhibition of hepatic glucose production[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 60 mg/ml (143.7 mM)
关键字: GSK-5182 | inhibit | GSK 5182 | Reactive Oxygen Species | Estrogen Receptor/ERR | GSK5182 | Inhibitor
相关产品: α-Zearalenol | Estradiol dipropionate | Droloxifene | 4-Hydroxyestrone | Genistin | Estrogen receptor modulator 7 | 4-hydroxyestrone-4-methyl ether | CIDD-0149897 | Prochloraz | Isocurcumenol
相关库: Anti-Prostate Cancer Compound Library | Anti-Breast Cancer Compound Library | Oxidation-Reduction Compound Library | NF-κB Signaling Compound Library | Bioactive Compounds Library Max | Nuclear Receptor Compound Library | Endocrinology-Hormone Compound Library | Metabolism Compound Library | Cuproptosis Compound Library | Bioactive Compound Library
Bioactivity
英文名: GSK5182
描述: GSK5182 是高效选择性，具有口服活性的 ERRγ反向激动剂，其 IC50=79 nM，且不与其他核受体相互作用，包括 ERRα 和 ERα。它还能增加肝癌细胞中 reactive oxyen species (ROS)的产生。
细胞实验: Cell Line:The human hepatoma cell line PLC/PRF/5. Concentration:0 μM, 10 μM, 20 μM. Incubation Time:0 hour, 24 hours, 48 hours, 72 hours
体外活性: Small interfering RNA (siRNA)-mediated knockdown of ERRγ (siRNA-ERRγ) or an ERRγ inverse agonist, GSK5182, were also used to examine the effects of ERRγ inhibition on the proliferation and growth of a human hepatoma cell line, PLC/PRF/5[1].
体内活性: a hyperinsulinemic-euglycemic clamp study and long-term studies of the antidiabetic effects of GSK5182, the ERRγ-specific inverse agonist, in db/db and DIO mice demonstrated that GSK5182 normalizes hyperglycemia mainly through inhibition of hepatic glucose production[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 60 mg/ml (143.7 mM)
关键字: GSK-5182 | inhibit | GSK 5182 | Reactive Oxygen Species | Estrogen Receptor/ERR | GSK5182 | Inhibitor
相关产品: α-Zearalenol | Estradiol dipropionate | Droloxifene | 4-Hydroxyestrone | Genistin | Estrogen receptor modulator 7 | 4-hydroxyestrone-4-methyl ether | CIDD-0149897 | Prochloraz | Isocurcumenol
相关库: Anti-Prostate Cancer Compound Library | Anti-Breast Cancer Compound Library | Oxidation-Reduction Compound Library | NF-κB Signaling Compound Library | Bioactive Compounds Library Max | Nuclear Receptor Compound Library | Endocrinology-Hormone Compound Library | Metabolism Compound Library | Cuproptosis Compound Library | Bioactive Compound Library
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