化合物GSK5182 T8370

Product Introduction
Bioactivity


英文名: GSK5182

描述: GSK5182 是高效选择性，具有口服活性的 ERRγ反向激动剂，其 IC50=79 nM，且不与其他核受体相互作用，包括 ERRα 和 ERα。它还能增加肝癌细胞中 reactive oxyen species (ROS)的产生。

细胞实验: Cell Line:The human hepatoma cell line PLC/PRF/5. Concentration:0 μM, 10 μM, 20 μM. Incubation Time:0 hour, 24 hours, 48 hours, 72 hours

体外活性: Small interfering RNA (siRNA)-mediated knockdown of ERRγ (siRNA-ERRγ) or an ERRγ inverse agonist, GSK5182, were also used to examine the effects of ERRγ inhibition on the proliferation and growth of a human hepatoma cell line, PLC/PRF/5[1].

体内活性: a hyperinsulinemic-euglycemic clamp study and long-term studies of the antidiabetic effects of GSK5182, the ERRγ-specific inverse agonist, in db/db and DIO mice demonstrated that GSK5182 normalizes hyperglycemia mainly through inhibition of hepatic glucose production[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/ml (143.7 mM)


关键字: GSK-5182 | inhibit | GSK 5182 | Reactive Oxygen Species | Estrogen Receptor/ERR | GSK5182 | Inhibitor

相关产品: α-Zearalenol | Estradiol dipropionate | Droloxifene | 4-Hydroxyestrone | Genistin | Estrogen receptor modulator 7 | 4-hydroxyestrone-4-methyl ether | CIDD-0149897 | Prochloraz | Isocurcumenol

相关库: Anti-Prostate Cancer Compound Library | Anti-Breast Cancer Compound Library | Oxidation-Reduction Compound Library | NF-κB Signaling Compound Library | Bioactive Compounds Library Max | Nuclear Receptor Compound Library | Endocrinology-Hormone Compound Library | Metabolism Compound Library | Cuproptosis Compound Library | Bioactive Compound Library

化合物GSK5182 T8370信息由TargetMol中国为您提供，如您想了解更多关于化合物GSK5182 T8370报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途