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Product IntroductionBioactivity英文名: Vardenafil hydrochloride描述: Vardenafil hydrochloride 是口服具有活性的、高效的、选择性的磷酸二酯酶 5抑制剂。它对 P
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Product Introduction
Bioactivity
英文名: Vardenafil hydrochloride
描述: Vardenafil hydrochloride 是口服具有活性的、高效的、选择性的磷酸二酯酶 5抑制剂。它对 PDE1 (180 nM)，PDE6 (11 nM)，PDE2，PDE3，PDE4 (>1000 nM) 具有选择性。它能够非竞争性地抑制环磷酸鸟苷水解，提高 cGMP 水平。它可用于勃起功能障碍的研究。
体内活性: After 12 weeks of treatment, a dose-dependent (P = 0.02) improvement in erections was noted for the GAQ, with 57 and 72% of men taking 10 mg or 20 mg vardenafil, respectively, reporting improved erections, in contrast to 13% after taking placebo (P < 0.0001). For the erectile function domain, dose-dependent (P = 0.03) final scores for the 10- and 20-mg dose were 17.1 and 19.0 compared with 12.6 for placebo (P < 0.0001). Both vardenafil doses significantly enhanced the rates of successful penetration (P < 0.0001) and successful intercourse (P < 0.0001) compared with placebo. Vardenafil treatment was effective in increasing intercourse success rates at all levels of baseline ED severity, at each level of plasma HbA(1c), and for type 1 and 2 diabetes. Treatment-emergent adverse events were primarily mild to moderate headache (
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (95.23 mM)
H2O : 100 mg/mL (190.45 mM)
关键字: Vardenafil Hydrochloride | PDE-5 inhibitors | Vardenafil | Endogenous Metabolite | diabetes | Zucker diabetic fatty (ZDF) rats | dysfunction | erectile dysfunction | Pharmacokinetics | Phosphodiesterase (PDE) | inhibit | selective | Vardenafil hydrochloride | Impotence | Inhibitor | smooth | erectile | muscle | stimulation | cGMP | hepatitis
相关产品: Mirodenafil dihydrochloride | EMD57439 | AN3199 | Balipodect | Pomiferin | Enpp-1-IN-14 | Zardaverine | Pterine-6-carboxylic acid | Difamilast | PF-05180999
相关库: FDA-Approved Drug Library | Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compounds Library Max | Inhibitor Library | EMA Approved Drug Library | Anti-Alzheimer's Disease Compound Library | Bioactive Compound Library
Bioactivity
英文名: Vardenafil hydrochloride
描述: Vardenafil hydrochloride 是口服具有活性的、高效的、选择性的磷酸二酯酶 5抑制剂。它对 PDE1 (180 nM)，PDE6 (11 nM)，PDE2，PDE3，PDE4 (>1000 nM) 具有选择性。它能够非竞争性地抑制环磷酸鸟苷水解，提高 cGMP 水平。它可用于勃起功能障碍的研究。
体内活性: After 12 weeks of treatment, a dose-dependent (P = 0.02) improvement in erections was noted for the GAQ, with 57 and 72% of men taking 10 mg or 20 mg vardenafil, respectively, reporting improved erections, in contrast to 13% after taking placebo (P < 0.0001). For the erectile function domain, dose-dependent (P = 0.03) final scores for the 10- and 20-mg dose were 17.1 and 19.0 compared with 12.6 for placebo (P < 0.0001). Both vardenafil doses significantly enhanced the rates of successful penetration (P < 0.0001) and successful intercourse (P < 0.0001) compared with placebo. Vardenafil treatment was effective in increasing intercourse success rates at all levels of baseline ED severity, at each level of plasma HbA(1c), and for type 1 and 2 diabetes. Treatment-emergent adverse events were primarily mild to moderate headache (
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (95.23 mM)
H2O : 100 mg/mL (190.45 mM)
关键字: Vardenafil Hydrochloride | PDE-5 inhibitors | Vardenafil | Endogenous Metabolite | diabetes | Zucker diabetic fatty (ZDF) rats | dysfunction | erectile dysfunction | Pharmacokinetics | Phosphodiesterase (PDE) | inhibit | selective | Vardenafil hydrochloride | Impotence | Inhibitor | smooth | erectile | muscle | stimulation | cGMP | hepatitis
相关产品: Mirodenafil dihydrochloride | EMD57439 | AN3199 | Balipodect | Pomiferin | Enpp-1-IN-14 | Zardaverine | Pterine-6-carboxylic acid | Difamilast | PF-05180999
相关库: FDA-Approved Drug Library | Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compounds Library Max | Inhibitor Library | EMA Approved Drug Library | Anti-Alzheimer's Disease Compound Library | Bioactive Compound Library
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