盐酸伐地那非 T8405

Product Introduction
Bioactivity


英文名: Vardenafil hydrochloride

描述: Vardenafil hydrochloride 是口服具有活性的、高效的、选择性的磷酸二酯酶 5抑制剂。它对 PDE1 (180 nM)，PDE6 (11 nM)，PDE2，PDE3，PDE4 (>1000 nM) 具有选择性。它能够非竞争性地抑制环磷酸鸟苷水解，提高 cGMP 水平。它可用于勃起功能障碍的研究。

体内活性: After 12 weeks of treatment, a dose-dependent (P = 0.02) improvement in erections was noted for the GAQ, with 57 and 72% of men taking 10 mg or 20 mg vardenafil, respectively, reporting improved erections, in contrast to 13% after taking placebo (P < 0.0001). For the erectile function domain, dose-dependent (P = 0.03) final scores for the 10- and 20-mg dose were 17.1 and 19.0 compared with 12.6 for placebo (P < 0.0001). Both vardenafil doses significantly enhanced the rates of successful penetration (P < 0.0001) and successful intercourse (P < 0.0001) compared with placebo. Vardenafil treatment was effective in increasing intercourse success rates at all levels of baseline ED severity, at each level of plasma HbA(1c), and for type 1 and 2 diabetes. Treatment-emergent adverse events were primarily mild to moderate headache (
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (95.23 mM)
H2O : 100 mg/mL (190.45 mM)


关键字: Vardenafil Hydrochloride | PDE-5 inhibitors | Vardenafil | Endogenous Metabolite | diabetes | Zucker diabetic fatty (ZDF) rats | dysfunction | erectile dysfunction | Pharmacokinetics | Phosphodiesterase (PDE) | inhibit | selective | Vardenafil hydrochloride | Impotence | Inhibitor | smooth | erectile | muscle | stimulation | cGMP | hepatitis

相关产品: Mirodenafil dihydrochloride | EMD57439 | AN3199 | Balipodect | Pomiferin | Enpp-1-IN-14 | Zardaverine | Pterine-6-carboxylic acid | Difamilast | PF-05180999

相关库: FDA-Approved Drug Library | Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compounds Library Max | Inhibitor Library | EMA Approved Drug Library | Anti-Alzheimer's Disease Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途