Product Introduction
Bioactivity


英文名: ACH-000143

描述: ACH-000143 是一种可口服的褪黑素受体激动剂，对 MT1 和 MT2 的EC50值分别为0.06 和0.32 nM。

体外活性: ACH-000143 demonstrated subnanomolar potency at MT1/MT2 receptors, high oral bioavailability in rodents, peripherally preferred exposure, and excellent selectivity in a broad panel of targets.

体内活性: 连续两月口服给予高脂饮食大鼠ACH-000143，其体重增长的减少效果与dapagliflozin相似，但在改善肝脂肪变性和三酸甘油脂水平方面表现出更优异的结果。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/ml (201.52 mM)


关键字: ACH000143 | Melatonin Receptor | HFD | toxicity | low | steatosis | Inhibitor | ACH 000143 | inhibit | ACH-000143 | obese

相关产品: 6-Chloromelatonin | Agomelatine | Ramelteon | 2-Iodomelatonin | Luzindole | Melatonin | 4-P-PDOT | Tasimelteon | N-ACETYLTRYPTAMINE

相关库: Histamine & Melatonin Receptor-Targeted Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | GPCR Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library