Product Introduction
Bioactivity


英文名: MB710

描述: MB710 是一种氨基苯并噻唑衍生物，是致癌 p53 突变体 Y220C 的稳定剂。MB710 与 Y220C 口袋紧密结合并稳定p53-Y220C，Kd 值为 4 μM。 MB710 在 p53-Y220C 细胞系中显示抗癌活性。

体外活性: MB710 (0-200 μM; 72 hours) shows relatively low toxicity against all tested cell lines at concentrations up to 60 μM, while showing initial selective viability reduction at higher concentrations [1]. MB710 (72 hours) treats cancer cell lines NUGC3, NUGC4, WI38 and SW1088, with IC 50 s of 90, 120, >120, >120 μM, respectively [1]. MB710 (0-120 μM; 72 hours; HUH-7 cells) shows stronger cytotoxic effects in presence of p53-Y220C [1]. Cell Viability Assay [1] Cell Line: NUGC3 (mutant p53 Y220C), HUH-7 (mutant p53 Y220C), NUGC4 (p53 WT), HUH-6 cells (p53 WT) Concentration: 0-200 μM Incubation Time: 72 hours Result: Showed relatively low toxicity against all cell lines tested at concentrations up to 60 μM. NUGC3 was the most sensitive cell line.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: MB-710 | MB710 | MB 710