化合物 MB710 T9661

Product Introduction
Bioactivity


英文名: MB710

描述: MB710 是一种氨基苯并噻唑衍生物，是致癌 p53 突变体 Y220C 的稳定剂。MB710 与 Y220C 口袋紧密结合并稳定p53-Y220C，Kd 值为 4 μM。 MB710 在 p53-Y220C 细胞系中显示抗癌活性。

体外活性: MB710 (0-200 μM; 72 hours) shows relatively low toxicity against all tested cell lines at concentrations up to 60 μM, while showing initial selective viability reduction at higher concentrations [1]. MB710 (72 hours) treats cancer cell lines NUGC3, NUGC4, WI38 and SW1088, with IC 50 s of 90, 120, >120, >120 μM, respectively [1]. MB710 (0-120 μM; 72 hours; HUH-7 cells) shows stronger cytotoxic effects in presence of p53-Y220C [1]. Cell Viability Assay [1] Cell Line: NUGC3 (mutant p53 Y220C), HUH-7 (mutant p53 Y220C), NUGC4 (p53 WT), HUH-6 cells (p53 WT) Concentration: 0-200 μM Incubation Time: 72 hours Result: Showed relatively low toxicity against all cell lines tested at concentrations up to 60 μM. NUGC3 was the most sensitive cell line.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: MB-710 | MB710 | MB 710

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途