氯化天竺葵素 TN1058
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Product IntroductionBioactivity英文名: Pelargonidin chloride描述: Pelargonidin chloride 是一种氧化氮自由基的清除剂，具有抗氧化作用。体外活性: The effect
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Product Introduction
Bioactivity
英文名: Pelargonidin chloride
描述: Pelargonidin chloride 是一种氧化氮自由基的清除剂，具有抗氧化作用。
体外活性: The effect of PC in ameliorating citrinin (CTN) induced cytotoxicity and oxidative stress. The cytotoxicity of CTN was evaluated by treating HepG2 (Human hepatocellular carcinoma) cells with CTN (0-150 μM) in a dose dependent manner for 24 h, and the IC50 was determined to be 96.16 μM. CTN increased lactate dehydrogenase leakage (59%), elevated reactive oxygen species (2.5-fold), depolarized mitochondrial membrane potential as confirmed by JC-1 monomers and arrested cell cycle at G2/M phase. Further, apoptotic and necrotic analysis revealed significant changes followed by DNA damage. To overcome these toxicological effects, PC was pretreated for 2 h followed by CTN exposure for 24 h. Pretreatment with PC resulted in significant increase in cell viability (84.5%), restored membrane integrity, reactive oxygen species level were maintained and cell cycle phases were normal. PC significantly up-regulated the activity of detoxification enzymes: heme oxygenase 1 (HO-1), glutathione transferase, glutathione peroxidase, superoxide dismutase and quinone reductase. Nrf2 translocation into the nucleus was also observed by immunocytochemistry analysis[1]
存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 10 mM
关键字: Inhibitor | Pelargonidin chloride | Pelargonidin Chloride | Pelargonidin | Radical | antioxidant | scavenger | inhibit | nitric oxide | Reactive Oxygen Species
相关产品: Micheliolide | Chlojaponilactone B | Tirucallol | Regaloside B | Cyclo(L-Pro-L-Val) | Bacoside A | Desoxo-narchinol A | Ruscogenin | Dehydromiltirone | MSU-42011
Bioactivity
英文名: Pelargonidin chloride
描述: Pelargonidin chloride 是一种氧化氮自由基的清除剂，具有抗氧化作用。
体外活性: The effect of PC in ameliorating citrinin (CTN) induced cytotoxicity and oxidative stress. The cytotoxicity of CTN was evaluated by treating HepG2 (Human hepatocellular carcinoma) cells with CTN (0-150 μM) in a dose dependent manner for 24 h, and the IC50 was determined to be 96.16 μM. CTN increased lactate dehydrogenase leakage (59%), elevated reactive oxygen species (2.5-fold), depolarized mitochondrial membrane potential as confirmed by JC-1 monomers and arrested cell cycle at G2/M phase. Further, apoptotic and necrotic analysis revealed significant changes followed by DNA damage. To overcome these toxicological effects, PC was pretreated for 2 h followed by CTN exposure for 24 h. Pretreatment with PC resulted in significant increase in cell viability (84.5%), restored membrane integrity, reactive oxygen species level were maintained and cell cycle phases were normal. PC significantly up-regulated the activity of detoxification enzymes: heme oxygenase 1 (HO-1), glutathione transferase, glutathione peroxidase, superoxide dismutase and quinone reductase. Nrf2 translocation into the nucleus was also observed by immunocytochemistry analysis[1]
存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 10 mM
关键字: Inhibitor | Pelargonidin chloride | Pelargonidin Chloride | Pelargonidin | Radical | antioxidant | scavenger | inhibit | nitric oxide | Reactive Oxygen Species
相关产品: Micheliolide | Chlojaponilactone B | Tirucallol | Regaloside B | Cyclo(L-Pro-L-Val) | Bacoside A | Desoxo-narchinol A | Ruscogenin | Dehydromiltirone | MSU-42011
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