氯化天竺葵素 TN1058

Product Introduction
Bioactivity


英文名: Pelargonidin chloride

描述: Pelargonidin chloride 是一种氧化氮自由基的清除剂，具有抗氧化作用。

体外活性: The effect of PC in ameliorating citrinin (CTN) induced cytotoxicity and oxidative stress. The cytotoxicity of CTN was evaluated by treating HepG2 (Human hepatocellular carcinoma) cells with CTN (0-150 μM) in a dose dependent manner for 24 h, and the IC50 was determined to be 96.16 μM. CTN increased lactate dehydrogenase leakage (59%), elevated reactive oxygen species (2.5-fold), depolarized mitochondrial membrane potential as confirmed by JC-1 monomers and arrested cell cycle at G2/M phase. Further, apoptotic and necrotic analysis revealed significant changes followed by DNA damage. To overcome these toxicological effects, PC was pretreated for 2 h followed by CTN exposure for 24 h. Pretreatment with PC resulted in significant increase in cell viability (84.5%), restored membrane integrity, reactive oxygen species level were maintained and cell cycle phases were normal. PC significantly up-regulated the activity of detoxification enzymes: heme oxygenase 1 (HO-1), glutathione transferase, glutathione peroxidase, superoxide dismutase and quinone reductase. Nrf2 translocation into the nucleus was also observed by immunocytochemistry analysis[1]

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 10 mM


关键字: Inhibitor | Pelargonidin chloride | Pelargonidin Chloride | Pelargonidin | Radical | antioxidant | scavenger | inhibit | nitric oxide | Reactive Oxygen Species

相关产品: Micheliolide | Chlojaponilactone B | Tirucallol | Regaloside B | Cyclo(L-Pro-L-Val) | Bacoside A | Desoxo-narchinol A | Ruscogenin | Dehydromiltirone | MSU-42011

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途