中文名：根赤壳菌素

英文名：Radicicol

中文别名：根赤壳霉素

英文别名：radicicol|Monorden|12772-57-5|Monorden A|(+)-Monorden A|I60EH8GECX|CHEMBL414883|CHEBI:556075|NSC-294404|(1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione|Monorderne|RDC|Ra

纯度：98%

货号：R102391

Cas号：12772-57-5

存储温度：-20°C储存,充氩

产品介绍：

Radicicol, a microbial cell differentiation modulator originally extracted from Neocosmospora tenuicristata, has been shown to inhibit proliferation and plasminogen activator production by vascular endothelial cells. Radicicol inhibits the expression of Cox-2 (IC50 = 27 nM) without affecting Cox-1 expression in LPS-stimulated macrophages. It is also a potent inhibitor of Hsp90. Experiments sμggest that radicicol reduces the intracellular level of autophosphorylation of p60v-src as well as other tyrosine-phosphorylated proteins via inhibition of SRC kinases. In addition, radicicol has demonstrated the ability to inhibit K-ras signaling pathway which includes phosphorylation of Raf-1, MAPKK, and MAPK.A potent inhibitor of Hsp90, SRC, and Cox-2

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