D129118-25g3,3'-亚甲基二吲哚
¥
699.00
- 阿拉丁
- 生产商
- D129118-25g
- 现货
- 全国
规格 |
---|
耗材描述
- 分子式 C17H14N2
- 分子量246.31
- MDL号 MFCD00195766
属性
熔点 | 165.0-171.0°C |
存贮条件 | 储存温度 2-8°C |
描述
应用 | An antineoplastic agent that activates Chk 2 and cytochrome p450 |
产品介绍 | 3,3'-Diindolylmethane is an anticancer and antineoplastic agent. 3,3'-Diindolylmethane induces apoptosis in human cancer cells. 3,3'-Diindolylmethane is also an activator of CYP (cytochrome P450) and Chk2 (checkpoint kinase 2) as well as a partial agonist of aryl hydrocarbon receptor (Ah Receptor). The compound is a dimer of indole-3-carbinol. |
生化机理 | Acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol.It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells.DIM induces a G1 cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H+-ATPase inhibitor.The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system. |
别名 | 二(3,3'-吲哚基)甲烷;3,3'-二吲哚甲烷;DIM;Di-3-indolylmethane; Plant Indole; 3,3’-Methylenediindole;DIM |
标识符号 | GHS07 |
信号词 | Warning |
危害声明 | H315,H319,H335,H413 |
警示性声明 | P261,P305+P351+P338 |
个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
WGK德国 | 3 |
风险声明 (欧洲) | R36/37/38 |
安全声明(欧洲) | S26 |
危害码(欧洲) | Xi |
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