In Vitro: PS432 (25 μM; 24 h) inhibits cancer cells proliferation, with IC50s of 30.7 μM (A549) and 12.4 μM (A427) in semi solid agar medium, for example. PS432 (50 μM; 12, 24, and 36 h) arrests cell cycle at G0/G1 phase in A549 lung cancer cells.
In Vivo: PS432 (2.5 mg/kg; i.p.; once daily for 14 d) inhibits tumor growth in xenograft model of lung cancer.