G126541-25mgGSK343
面议
- 阿拉丁
- 生产商
- G126541-25mg
- 现货
- 全国
规格 |
---|
耗材描述
- 分子式 C31H39N7O2
- 分子量541.69
属性
溶解性 | DMSO: soluble15 mg/mL, clear |
存贮条件 | 储存温度2-8℃ |
描述
应用 | An inhibitor of the histone lysine methyltransferase ENX-1.It is an epigenetic chemical probe available through a partnership between Sigma Life Science and the Structural Genomics Consortium (SGC). |
产品介绍 | It is an epigenetic chemical probe available through a partnership between Sigma Life Science and the Structural Genomics Consortium (SGC). |
生化机理 | It is a potent, specific inhibitor of the histone H3-lysine 27 (H3K27) methyltransferase EZH2. GSK343 inhibits EZH2 enzymatic activity with an IC50 of 4 nM. The compound displays 60 fold selectivity for EZH2 vs. EZH1, and 1000 fold or greater selectivity against other histone methyltransferases. The IC50 for inhibition of H3K27 methylation is < 200 nM in HCC1806 cells. |
别名 | 1-异丙基-N-[(6-甲基-2-氧代-4-丙基-1,2-二氢-3-吡啶基)甲基]-6-[2-(4-甲基-1-哌嗪基)-4-吡啶基]-1H-吲唑-4-甲酰胺;N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide |
猜你喜欢
感兴趣产品