S129623-100mgStattic
面议
- 阿拉丁
- 生产商
- S129623-100mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C8H5NO4S
- 分子量211.19
属性
沸点 | 461.1° C |
熔点 | 129.80° C |
折光率 | 1.67 |
溶解性 |
|
存贮条件 | 储存温度-20°C |
密度 | 1.6000 |
描述
应用 | An inhibitor of Stat3 activation |
产品介绍 | Stattic是STAT3的有效抑制剂,主要用于癌症的治疗。 |
备注 | Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1. |
生化机理 | Stat3 Inhibitor V, Stattic is a small molecule shown to selectively inhibit the activation of the Stat3 transcription factor by blocking phosphorylation and dimerization events. Stattic has been used as a tool for probing the upstream activation of this factor, significantly expressed in many cancer cell lines, and interruption of this pathway in breast cancer cell lines lead to an increased apoptotic rate in these cells. Stat3 Inhibitor V, Stattic is an inhibitor of Stat3. |
别名 | ;Stat three inhibitory compound:6-Nitrobenzo[b]thiophene-1,1-dioxide; 6-Nitrobenzo[b]thiophene-1,1-dioxide |
标识符号 | GHS07 |
信号词 | Warning |
危害声明 | H315-H319-H335 |
警示性声明 | P261-P305 + P351 + P338 |
个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
WGK德国 | 3 |
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