Stattic
面议
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分子式 C8H5NO4S 分子量211.19 属性 沸点 461.1° C 熔点 129.80° C 折光率 1.67 溶解性 DMSO 42 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 存贮条件
| 货号 | CAS号 | 操作 |
|---|---|---|
| S129623-100mg | 19983-44-9 | 询底价 |
| S129623-25mg | 19983-44-9 | 询底价 |
耗材描述
- 分子式 C8H5NO4S
- 分子量211.19
属性
| 沸点 | 461.1° C |
| 熔点 | 129.80° C |
| 折光率 | 1.67 |
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.6000 |
描述
| 应用 | An inhibitor of Stat3 activation |
| 产品介绍 | Stattic是STAT3的有效抑制剂，主要用于癌症的治疗。 |
| 备注 | Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1. |
| 生化机理 | Stat3 Inhibitor V, Stattic is a small molecule shown to selectively inhibit the activation of the Stat3 transcription factor by blocking phosphorylation and dimerization events. Stattic has been used as a tool for probing the upstream activation of this factor, significantly expressed in many cancer cell lines, and interruption of this pathway in breast cancer cell lines lead to an increased apoptotic rate in these cells. Stat3 Inhibitor V, Stattic is an inhibitor of Stat3. |
| 别名 | ;Stat three inhibitory compound:6-Nitrobenzo[b]thiophene-1,1-dioxide; 6-Nitrobenzo[b]thiophene-1,1-dioxide |
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