G129772-250mgGW501516
面议
- 阿拉丁
- 生产商
- G129772-250mg
- 现货
- 全国
规格 |
---|
耗材描述
- 分子式 C21H18F3NO3S2
- 分子量453.50
- Beilstein号 18515150
- EC号 MFCD09033000
- MDL号 MFCD09033000
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
产品介绍 |
{2- |
备注 | GW501516 is a potent and highly selective PPARβ/δ agonist, with EC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ. Phase 4. |
生化机理 |
GW501516 (GW1516 or GSK-516) is a drug that acts as a PPARδ modulator. GW 501516 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue, and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation. It has been proposed as a potential treatment for obesity and related conditions, especially when used in conjunction with a synergistic compound AICAR, as the combination has been shown to significantly increase exercise endurance in animal studies. |
别名 | GW1516, GSK-516, GW-501516;2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio)phenoxy)acetic acid;GW1516, GSK-516, GW-501516;2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio)phenoxy)acetic acid |
RTECS | AI9105500 |
猜你喜欢
感兴趣产品