A129701-25mgAzasetron HCl
面议
- 阿拉丁
- 生产商
- A129701-25mg
- 现货
- 全国
规格 |
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耗材描述
属性
熔点 | 301-303 °C |
溶解性 | Soluble in water (25 mg/ml), and DMSO (10 mM). |
存贮条件 | 储存温度-20°C |
描述
应用 | A potent and selective SR-3 antagonist |
产品介绍 | Azasetron HCl是一种选择性5-HT3受体拮抗剂,IC50为0.33 nM,用于癌症化疗引起的恶心和呕吐。 |
备注 | Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy. |
生化机理 | Y-25130 Hydrochloride is a potent and selective SR-3 antagonist. This product was demonstrated to be an antiemetic agent valuable for countering adverse effects seen in anticancer therapy including cisplatin. In studies involving rat hippocampal slices, Y-25130 exhibited dose-dependent neuroprotective effects against an ischemia-induced decrease in CA1 field potential. It has also been reported to attenuate the cocaine-induced decrease of intracranial self-stimulation (ICSS) reward thresholds in rats. Other results of the SR-3 antagonistic activity of Y-25130 led to the acceleration of gastric emptying in mice. |
别名 | 盐酸阿扎司琼; N-(1-氮杂双环[2.2.2]辛-8-基)-6-氯-4-甲基-3-氧代-3,4-二氢-2H-1,4-苯并恶嗪-8-甲酰胺盐酸盐;N-(1-Azabicyclo[2.2.2]octan-8-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide hydrochloride;Y-25130 hydrochloride; Y25130 hydrochloride; Y 25130 hydrochloride;Azasetron hydrochloride |
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