| 应用 |
A potent and selective SR-3 antagonist |
| 产品介绍 |
Azasetron HCl是一种选择性5-HT3受体拮抗剂，IC50为0.33 nM，用于癌症化疗引起的恶心和呕吐。 |
| 备注 |
Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy. |
| 生化机理 |
Y-25130 Hydrochloride is a potent and selective SR-3 antagonist. This product was demonstrated to be an antiemetic agent valuable for countering adverse effects seen in anticancer therapy including cisplatin. In studies involving rat hippocampal slices, Y-25130 exhibited dose-dependent neuroprotective effects against an ischemia-induced decrease in CA1 field potential. It has also been reported to attenuate the cocaine-induced decrease of intracranial self-stimulation (ICSS) reward thresholds in rats. Other results of the SR-3 antagonistic activity of Y-25130 led to the acceleration of gastric emptying in mice. |
| 别名 |
盐酸阿扎司琼; N-(1-氮杂双环[2.2.2]辛-8-基)-6-氯-4-甲基-3-氧代-3,4-二氢-2H-1,4-苯并恶嗪-8-甲酰胺盐酸盐;N-(1-Azabicyclo[2.2.2]octan-8-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide hydrochloride;Y-25130 hydrochloride; Y25130 hydrochloride; Y 25130 hydrochloride;Azasetron hydrochloride |
