H126738-50mgHC-030031
面议
- 阿拉丁
- 生产商
- H126738-50mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C18H21N5O3
- 分子量355.39
- Beilstein号
- EC号 MFCD02007349
- MDL号 MFCD02007349
- PubChem编号
属性
沸点 | 650.65° C |
熔点 | 221-223° C |
折光率 | 1.65 |
溶解性 |
|
密度 | 1.3300 |
描述
应用 | A potent and selective TRPA1 inhibitor |
产品介绍 | HC-030031是TRPA1通道阻断剂,能拮抗AITC和福尔马林诱发的钙流,IC50分别为6.2 μM和5.3 μM。 |
生化机理 | HC-030031 is a substituted theophylline derivative. Potent and selective ANKTM1 (TRPA1) inhibitor. It antagonizes allyl isothiocyanate (AITC)- and formalin-evoked calcium influx with IC50 values of 6.2 and 5.3 μM respectively. Both inward and outward currents elicited by AITC or formalin are rapidly and reversibly blocked by HC-030031 which also blocks the activation of TRPA1 by N-methylmaleimide and by electrophillic prostaglandins2. TRPV1, TRPV3, TRPV4, hERG and NaV1.2 are not blocked. |
别名 | HC 030031;HC030031; 1,2,3,6-四氢-1,3-二甲基-N-(4-(1-甲基乙基)苯基)-2,6-二氧代-7H-嘌呤-7-乙酰胺;;HC 030031;HC030031; 1,2,3,6-Tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo-7H-purine-7-acetamide ;2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide |
标识符号 |
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信号词 | Danger |
危害声明 | H301 |
警示性声明 | P301 + P310 |
个人防护设备 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
WGK德国 | 3 |
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