F129894-1gFluticasone propionate
面议
- 阿拉丁
- 生产商
- F129894-1g
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C25H31F3O5S
- 分子量500.57
- Beilstein号
- EC号 MFCD00866007
- MDL号 MFCD00866007
- PubChem编号
属性
熔点 | 275°C(lit.) |
溶解性 |
|
描述
应用 | A high-affinity, selective glucocorticoid receptor agonist. |
产品介绍 | Fluticasone propionate 是一种合成的皮质类固醇,是Fluticasone的衍生物,用于治疗哮喘和过敏性鼻炎(花粉症)。 |
备注 | Fluticasone propionate (Flonase, Veramyst) is a synthetic corticosteroid which is derived from fluticasone used to treat asthma and allergic rhinitis (hay fever). |
生化机理 | Fluticasone propionate is a high affinity, selective glucocorticoid receptor (GR) agonist (Kd = 0.5 nM). Fluticasone propionate potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Fluticasone propionate is a lipophilic anti-inflammatory agent derived from flumethasone. |
别名 | 丙酸氟替卡松;氟替卡松丙酸酯;6,9-二氟-11羟基甲基氧代(氧代丙氧基)雄甾,二烯硫代羧酸-S-氟甲酯;(6α,11β,16α,17α)-6,9-二氟-11-羟-16-甲基-3-氧代-17-(1-氧代丙氧基)-雄甾-1,4-二烯-17-硫代羧酸 S-(氟甲基)酯;Flonase; Veramyst;(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester;S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate; |
Reaxys-RN | 6944704 |
个人防护设备 | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
RTECS | BV7980000 |
WGK德国 | 2 |
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