CYC116-分析测试百科网

CYC116

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：3
近期咨询：0

分子式 C18H20N6OS 分子量368.46 属性溶解性 DMSO 24 mg/mL heatWater <1 mg/mL Ethanol <1 mg/mL 存贮条件储存温度-20°C //decorateTable('

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
C126929-10mg	693228-63-6	询底价
C126929-1mg	693228-63-6	询底价
C126929-50mg	693228-63-6	询底价

耗材描述

分子式 C₁₈H₂₀N₆OS
分子量368.46

属性

溶解性	DMSO 24 mg/mL heat Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C

描述

备注	CYC116 is a potent inhibitor of Aurora A/B with K_i of 8.0 nM/9.2 nM, is less potent to VEGFR2 (K_i of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK
生化机理	CYC-116 is an orally bioavailable，small molecule Aurora kinase/VEGFR2 inhibitor with antineoplastic activity. CYC-116 inhibits Aurora kinases A and B and VEGFR2, resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis.
别名	4-(2-amino-4-methylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine;4-(2-amino-4-methylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine

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