Hesperadin-分析测试百科网

Hesperadin

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：3
近期咨询：0

分子式 C29H32N4O3S 分子量516.67 属性熔点 >226 °C 溶解性 DMSO 103 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 存贮条件储存温度-20°C 密度 1.

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
H126784-5mg	422513-13-1	询底价
H126784-100mg	422513-13-1	询底价
H126784-25mg	422513-13-1	询底价

耗材描述

分子式 C₂₉H₃₂N₄O₃S
分子量516.67

属性

熔点	>226 °C
溶解性	DMSO 103 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C
密度	1.3000

描述

产品介绍	Hesperadin是ATP竞争性Aurora B抑制剂，IC50为250 nM。
生化机理	esperadin prevents the phosphorylation of recombinant trypanosome histone H3 by the T. brucei Aurora kinase-1 (TbAUK1) from pathogenic Trypanosoma brucei with IC50 of 40 nM in vitro kinase assays. Hesperadin significantly inhibits cell growth of cultured infectious bloodstream forms (BF) with IC50 of 48 nM, and only weakly inhibits cell growth of insect stage procyclic forms (PF) with IC50 of 550 nM. Hesperadin inhibits the ability of immunoprecipitated Aurora B to phosphorylate histone H3 with IC50 of 250 nM and markedly reduces the activity of other kinases (AMPK, Lck, MKK1, MAPKAP-K1, CHK1, and PHK) at a concentration of 1 μM.
别名	N-(2,3-二氢-2-氧代-3-((3Z)-苯基((4-(1-哌啶基甲基)苯基)氨基)亚甲基)-1H-吲哚-5-基)乙磺酰胺;;hesperadine；N-[2,3-Dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]-ethanesulfonamide; N-[(3Z)-2,3-Dihydro-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]ethanesulfonamide

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