C126929-50mg&CYC116
面议
- 阿拉丁
- 生产商
- C126929-50mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C18H20N6OS
- 分子量368.46
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
备注 | CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK |
生化机理 |
CYC-116 is an orally bioavailable,small molecule Aurora kinase/VEGFR2 inhibitor with antineoplastic activity. CYC-116 inhibits Aurora kinases A and B and VEGFR2, resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. |
别名 | 4-(2-amino-4-methylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine;4-(2-amino-4-methylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine |
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