Vorinostat
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分子式 C14H20N2O3 分子量264.32 Beilstein号 EC号 MDL号 MFCD00945317 PubChem编号 属性 敏感性 对热敏感 溶解性 Soluble in ethanol (3 mg/ml at 25 °C
| 货号 | CAS号 | 操作 |
|---|---|---|
| V125336-100mg | 149647-78-9 | 询底价 |
| V125336-1g | 149647-78-9 | 询底价 |
| V125336-500mg | 149647-78-9 | 询底价 |
| V125336-5g | 149647-78-9 | 询底价 |
耗材描述
- 分子式 C14H20N2O3
- 分子量264.32
- Beilstein号
- EC号
- MDL号 MFCD00945317
- PubChem编号
属性
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in ethanol (3 mg/ml at 25 °C), DMSO (53 mg/ml at 25 °C), DMF (~20 mg/ml), water (1.17 mg/ml at 25 °C), and methanol. |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 |
A potent HDAC inhibitor; also causes cell cycle arrest at G1 SAHA可用于研究基因调控、转录调控和细胞信号转导。 |
| 产品介绍 | Suberoylanilide Hydroxamic Acid (SAHA) is a potent histone deacetylase (HDAC) inhibitor that has been shown to inhibit proliferation and cause cell cycle arrest at G1. Experiments suggest that SAHA also causes morphological changes, such as enlargement and flattening of the cytoplasm, resulting in growth inhibition. Treatment of cells with SAHA also decreases the expression of anti-apoptosis proteins Bcl-xL and survivin. |
| 备注 | Vorinostat (suberoylanilide hydroxamic acid, SAHA, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM. |
| 生化机理 | SAHA或Vorinostat可促进导致细胞凋亡、分化和生长停滞的基因的转录。其已在淋巴瘤中获得有益结果，但在实体瘤中没有。 立诺他或辛二酰苯胺异羟肟酸（SAHA）是一种有效的、可逆的泛组蛋白去乙酰化酶（HDAC）抑制剂。其可抑制I类和II类HDAC，从而改变基因转录并诱导多种转化细胞中的细胞周期停滞和/或凋亡。 |
| 别名 | SAHA;异羟肟酸;N-羟基-N'-苯基辛二酰胺;伏立诺他;MK0683;辛二酰苯胺异羟肟酸 ;SAHA;N-hydroxy-N′-phenyl-octanediamide;Suberoylanilide hydroxamic acid |
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