Entinostat (MS-275)-分析测试百科网

Entinostat (MS-275)

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：4
近期咨询：1

分子式 C21H20N4O3 分子量376.41 MDL号 MFCD03453552 属性溶解性 Soluble in methanol, DMSO (~30 mg/ml), DMF (~30 mg/ml), ethanol (~2 mg

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
E125068-50mg	209783-80-2	询底价
E125068-10mg	209783-80-2	询底价
E125068-100mg	209783-80-2	询底价
E125068-250mg	209783-80-2	询底价

耗材描述

分子式 C₂₁H₂₀N₄O₃
分子量376.41
MDL号 MFCD03453552

属性

溶解性	Soluble in methanol, DMSO (~30 mg/ml), DMF (~30 mg/ml), ethanol (~2 mg/ml), 1:1 solution of DMSO:PBS(PH7.2) (~0.5 mg/ml), and water (<1 mg/ml) at 25 °C.
存贮条件	储存温度-20°C

描述

应用	An HDAC inhibitor shown to inhibit angiogenesis and metastasis.
产品介绍	Entinostat (MS-275)对HDAC1和HDAC3抑制作用强于与HDACs 4， 6， 8，和10，IC50分别为0.51 μM和1.7 μM。
备注	Entinostat (MS-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, compared with HDACs 4, 6, 8, and 10. Phase 1/2.
生化机理	MS-275 is an inhibitor of HDAC (histone deacetylase) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM). However, MS-275 does not inhibit HDAC8 (IC50 > 100 μM). MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo. Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs, like adriamycin, inhibitors of poly (ADP-ribose) polymerase (PARP), or inhibitors of heat shock protein 90 (Hsp90).
别名	SNDX-275;恩替诺特; N-[[4-[[(2-氨基苯基)氨基]甲酰]苯基]甲基]氨基甲酸 3-吡啶基甲基酯;MS-275; SNDX-275; MS 275; SNDX 275;A HDAC1 and HDAC3 inhibitor;3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate; N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide

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