耗材描述

• 分子式 C₁₇H₂₂N₂O₃
• 分子量302.37
• MDL号 MFCD03848392
• PubChem编号 24900542

属性

敏感性	对热敏感
溶解性	Soluble in water (Partly Miscible), ethanol (2 mg/mL), DMSO (20 mg/mL), acetonitrile, DMF (30 mg/mL), and methanol
存贮条件	储存温度-20°C

描述

应用	A potent and non-competitive reversible inhibitor of HDAC.
产品介绍	Trichostatin A (TSA)是一种HDAC抑制剂，IC50为1.8 nM左右，HDAC8是HDAC家族中唯一不受TSA影响的成员。
备注	Trichostatin A (TSA) is an HDAC inhibitor with IC50 of ~1.8 nM – HDAC8 is the only known member of the HDAC-family that is not affected by TSA. Phase 3.
生化机理	Trichostatin A (TSA) is a potent and non-competitive reversible inhibitor of histone deacetylases (HDAC) with a Ki of 3.4 nM. In HeLa cells, TSA blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin. In cells latently infected with HIV-1, TSA induced the transcriptional activation of the HIV-1 promoter, which resulted in a marked increase in virus production. In NIH 3T3 cells, TSA induced reversion of oncogenic ras-transformed cells to a normal morphology. In Jurkat cells, TSA inhibited IL-2 gene expression and displayed immunosuppressive activity in a mouse model. Induces increased acetylation of GATA4, a cardiac-specific transcription factor and increases cardiac muscle cell differentiation. In normal fibroblasts, induced Friend cell differentiation and inhibited the G1 and G2 phases of the cell cycle.
别名	TSA;曲古抑菌素 A;曲古柳菌素A ;TSA; R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

标识符号	GHS07
信号词	Warning
危害声明	H302-H312-H315-H317-H319-H332-H335
警示性声明	P261-P280-P305 + P351 + P338
个人防护设备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECS	MI5215000
WGK德国	3

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