耗材描述

• 分子式 C₂₄H₂₆N₄O₄
• 分子量434.49

属性

溶解性	DMSO ≥40mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
存贮条件	储存温度-20°C

描述

应用	A potent inhibitor of HDACs and receptor tyrosine kinases
产品介绍	CUDC-101是HDAC，EGFR和HER2抑制剂，IC50分别为4.4，2.4和15.7 nM。
备注	CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1.
生化机理	CUDC-101 inhibits the erlotinib-resistant EGFR mutant T790M although its effects are incomplete with an Amax of ~60% of peak enzyme activity after inhibition. CUDC-101 treatment increases the acetylation of histone H3 and H4, as well as the acetylation of non-histone substrates of HDAC such as p53 and α-tubulin, in a dose-dependant manner in various cancer cell lines. CUDC-101 also suppresses HER3 expression, Met amplification, and AKT reactivation in tumor cells.
别名	7-((4-(3-乙炔基苯基氨基)-7-甲氧基喹唑啉-6-基)氧基)-N-羟基庚酰胺;;CUDC101;CUDC 101;7-((4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yl)oxy)-n-hydroxyheptanamide

猜你喜欢

• 

  CUDC-101

• 

  SRT1720

• 

  Mocetinostat (MGCD0103)

• 

  Vorinostat

• 

  Rocilinostat (ACY-1215)

• 

  EX 527 (Selisistat)

• 

  Tubastatin A HCl

• 

  AR-42

• 

  RGFP966

• 

  Belinostat (PXD101)

感兴趣产品

• CUDC-101价格
• CUDC-101厂商
• CUDC-101规格