M126487-2mgMLN0905
面议
- 阿拉丁
- 生产商
- M126487-2mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C24H25F3N6S
- 分子量486.56
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
备注 | MLN0905 is a potent inhibitor of PLK1 with IC50 of 2 nM. |
生化机理 |
MLN0905, a small-molecule PLK1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphoma. PLK1 inhibition leads to pharmacodynamic pHisH3 modulation and significant antitumor activity in multiple DLBCL models. MLN0905 modulates the pharmacodynamic biomarker phosphorylated histone H3 (pHisH3) in tumor tissue. |
别名 | 6H-Pyrimido[5,4-d][1]benzazepine-6-thione, 2-[[5-[3-(dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)-;6H-Pyrimido[5,4-d][1]benzazepine-6-thione, 2-[[5-[3-(dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)- |
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