耗材描述

• 分子式 C₃₁H₃₃N₂O₃·HCl
• 分子量553.53
• Beilstein号
• EC号 MFCD18385010
• MDL号
• PubChem编号

属性

溶解性	DMSO 111 mg/mL Water 22 mg/mL Ethanol 111 mg/mL
存贮条件	储存温度-20°C

描述

产品介绍	SB-743921是第二代高活性KSP抑制剂，Ki为0.1 nM，对MKLP1，Kin2，Kif1A，Kif15，KHC，Kif4和CENP-E无亲和力。
生化机理	SB-743921 is greater efficacy in vivo against P388 leukemia. SB-743921 has significant efficacy in a broad spectrum of tumor models differing from that of taxanes. SB-743921 is shown to have activity against advanced human tumor xenografts Colo205 (complete regressions), MCF-7, SK-MES, H69, OVCAR-3 (complete and partial regressions), and HT-29, MX-1, MDA-MB-231, A2780 (tumor growth delay). SB-743921 doesn't cause the neuropathy often associated with the tubulin agents.
别名	SB743921; SB 743921; N-(3-氨基丙基)-N-((1R)-1-(7-氯-4-氧代-3-(苯基甲基)-4H-1-苯并吡喃-2-基)-2-甲基丙基)-4-甲基苯甲酰胺盐酸盐;;SB743921; SB 743921；（R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylbenzamide hydrochloride

WGK德国

3

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