FIDAS-3 | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 11900 |
性能特点
FIDAS-3 是一种二苯乙烯衍生物,也是一种强效的 Wnt 抑制剂,对甲硫氨酸腺苷转移酶 2A (MAT2A) 的 IC50 为 4.9 μM。FIDAS-3 与 S-腺苷甲硫氨酸 (SAM
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 1266684-01-8 | ¥571.00 | 询底价 |
5 mg | 1266684-01-8 | ¥1,300.00 | 询底价 |
10 mg | 1266684-01-8 | ¥2,400.00 | 询底价 |
25 mg | 1266684-01-8 | ¥4,600.00 | 询底价 |
50 mg | 1266684-01-8 | ¥7,500.00 | 询底价 |
100 mg | 1266684-01-8 | ¥11,900.00 | 询底价 |
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CAS No. : 1266684-01-8
MCE 国际站:FIDAS-3
产品活性:FIDAS-3 是一种二苯乙烯衍生物,也是一种强效的 Wnt 抑制剂,对甲硫氨酸腺苷转移酶 2A (MAT2A) 的 IC50 为 4.9 μM。FIDAS-3 与 S-腺苷甲硫氨酸 (SAM) 有效竞争 MAT2A 结合,并具有抗癌活性。
研究领域:Stem Cell/Wnt
作用靶点:Wnt
In Vitro: FIDAS-3 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells.
FIDAS-3 (3-10 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-3 induces the expression of cell cycle inhibitor, p21WAF1/CIP1.
FIDAS-3 (10 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells.
In Vivo: FIDAS-3 (20 mg/kg; intraperitoneal injection; daily; for one months; C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors.
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