Tanshinone I | 丹参酮 I | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 400 |
性能特点
Tanshinone I 是一种IIA型人重组 sPLA2 和兔重组 cPLA2 抑制剂,IC50 分别为 11 μM 和 82 μM。
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 568-73-0 | ¥400.00 | 询底价 |
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
Tanshinone I
CAS No. : 568-73-0
MCE 国际站:Tanshinone I
产品活性:Tanshinone I 是一种IIA型人重组 sPLA2 和兔重组 cPLA2 抑制剂,IC50 分别为 11 μM 和 82 μM。
研究领域:Metabolic Enzyme/Protease
作用靶点:Phospholipase
In Vitro: Tanshinone I inhibits PGE2 formation from LPS-induced RAW macrophages (IC50=38 μM). When Tanshinone I is added simultaneously with LPS, this compound clearly inhibits PGE2 production (IC50=38 μM) at 10-100 μM. Tanshinone I also reduces PGE2 production (IC50=46 μM) when added after COX-2 is fully induced. The fact that Tanshinone I inhibits PGE2 production by pre-induced COX-2 strongly suggests that this compound may directly inhibit COX-2 activity and/or affect PLA2 activity. When Tanshinone I is incubated with two different forms of phospholipase A2 (PLA2), it clearly inhibits sPLA2 (IC50=11 μM) in a concentration-dependent manner. Although being less potent, Tanshinone I also inhibits cPLA2 (IC50=82 μM).
In Vivo: Tanshinone I shows antiinflammatory activity in rat carrageenan-induced paw oedema and adjuvant-induced arthritis. In order to establish the anti-inflammatory activity of Tanshinone I, the classical animal models of acute and chronic inflammation [rat carrageenan (CGN)-induced paw oedema and rat adjuvant-induced arthritis (AIA)] are employed. When Tanshinone I is orally administered, it shows significant anti-inflammatory activity against CGN-induced paw oedema (47% inhibition at 160 mg/kg), while the IC50 of indomethacin is 7.1 mg/kg. In AIA, Tanshinone I gives 27% inhibition of secondary inflammation at 18 day with an oral dose of 50 mg/kg/day, whereas prednisolone (5 mg/kg/day) shows potent inhibition (65%).
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Cardiovascular Disease Compound Library | Terpenoids Library | Traditional Chinese Medicine Active Compound Library | Lipid Metabolism Compound Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Non-steroidal Anti-Inflammatory Compound Library | Metabolic Enzyme Compound Library | GW4869 | Neomycin sulfate | U-73122 | BAPTA | Compound 48/80 trihydrochloride | Omeprazole | ML348 | D609 | Darapladib | ML349 | m-3M3FBS | Lansoprazole | Varespladib | N-(p-amylcinnamoyl) Anthranilic Acid | AACOCF3 | Tris(2,4-di-tert-butylphenyl)phosphate | CAY10650 | FIPI | MAFP | DPTIP | LEI-401 | LFHP-1c | Manumycin A | U-73343 | AA26-9 | Melittin | Bromoenol lactone | CCT129957 | 3-Nitrocoumarin
热门产品线:重组蛋白 | 药物筛选 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。
![MCE Hotline: 4008203792 | 中国现货 - 全球文献引用 - 高纯度高品质 - 全方位技术支持](https://file.medchemexpress.cn/web-groups/product-type/7.jpg)
Tanshinone I | 丹参酮 I | MedChemExpress (MCE)信息由MedChemExpress (MCE)为您提供,如您想了解更多关于Tanshinone I | 丹参酮 I | MedChemExpress (MCE)报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途